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Author Topic: Best meds for sick baby?  (Read 1437 times)
Noe
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« on: May 01, 2003, 02:26:31 PM »

Poor Elmo! Last night I noticed him sneezing and breathing audibly, and this morning he was much worse. I can feel his breathing, it rattles and is very loud, and he's lethargic. He's seeing the vet tomorrow but I wanted to check here and see if anyone has any advice about what I should discuss with her.

He's only 3 weeks old so Baytril isn't an option; after looking at the (somewhat outdated) Drug Interaction Chart, I was thinking Doxy or possibly Zithro. She is a good vet but has only prescribed Zithro once for a rat; it was Anubis, and at that point he was just too far gone. Any ideas?

Anyway, wish him well; I'll keep you updated on what happens. I still can't believe that he seemed perfectly healthy yesterday when I took this picture:

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« Reply #1 on: May 01, 2003, 02:41:50 PM »

I would ask the vet to do zithro first.  Sounds like a stronger drug.
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« Reply #2 on: May 01, 2003, 03:45:56 PM »

I would ask the vet to do zithro first.  Sounds like a stronger drug.

When we dropped off Cephie today the vet wasn't in, but I asked the receptionist to tell her I wanted Zithro if possible, and she sounded very receptive about it.
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« Reply #3 on: May 01, 2003, 04:35:20 PM »

I agree w/ the Zithro, I'd try that first, you may want to check the dosage with Debbie D to make sure he's getting enough (and conversly, not too much).  If that doesn't work, you could move onto something stronger like Baytril, or a doxy/baytil combo.  I've yet to see any concrete evidence that it actually stunts growth in *rats*, so that shouldn't be much of a concern.
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« Reply #4 on: May 01, 2003, 04:41:03 PM »

what a cutie! I hope he gets better soon  Heart
can I ask why baytril wouldnt be an option? I checked the drug chart but it didnt give a reason.
(I ask because my old vet put my 5 week old on baytril)  Angry
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« Reply #5 on: May 01, 2003, 04:43:57 PM »

It's been shown that Baytril stunts grown in large breed dogs and in rabbits so some  vets don't use it in animals under 2 months.
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« Reply #6 on: May 01, 2003, 04:46:44 PM »

*kim whispers again that it does not stunt the growth, it affects the cartilage formation***
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« Reply #7 on: May 01, 2003, 04:54:30 PM »

*kim whispers again that it does not stunt the growth, it affects the cartilage formation***

Yup, even Baytril.com admits that.

http://www.kuddlykorner4u.com/Enrofloxacin.html
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« Reply #8 on: May 02, 2003, 09:17:19 AM »

Hoping for the best for your little guy.
He's aorable by the way.
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« Reply #9 on: May 02, 2003, 03:43:49 PM »

...or TMS can be given safely to little baby rats. Hope he's feeling better soon!
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« Reply #10 on: May 02, 2003, 06:59:59 PM »

We ended up going with Doxy. The vet didn't want to use a stronger med if we don't need it, because if he turns out to be a chronic sickie there won't be any big guns in reserve. She thinks it may be a virus, but the purpose of the antibiotics is to suppress the myco so the immune system can fight back. (TMS doesn't directly attack myco, which is why it wasn't an option for him.)

I'll keep you all updated on how he fairs. Thank you, everyone, for the advice.
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« Reply #11 on: May 03, 2003, 09:04:58 AM »

Can anyone point me to a documented clinical study on enrofloxacin's effects on young rodents? Or perhaps a personal experience with the joint damage caused by the medication ?

I have managed to locate peer review studies on cats, dogs, and horses, but not a single shred ( besides hearsay ) on rodents.

This bothers me as we are taking six week old Bella to the Vet today, and I have a sneaky suspicion she will recommend enrofloxacin as she did with Butter last year. Butter was also six to seven weeks at the time.

I have no problem gently *demanding* the azithromycin or doxy, as you all know I can be a tad outspoken Wink , but I would also like some clinical documentation ( other than the previous animals mentioned ) to back up my claim.

Thanks guys,

Roger
« Last Edit: May 03, 2003, 09:49:42 AM by ratpaws_roger » Logged

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« Reply #12 on: May 03, 2003, 10:02:18 AM »

That's just it, Roger, there isn't any documentation. Only speculation. The documentation only exists for dogs & cats.
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« Reply #13 on: May 03, 2003, 10:35:04 AM »

Humpf...... just our luck. The single most "tested on" animal in the world, and not a scrap pertaining to this.

I am guessing that we should pursue the Doxy. Like little Elmo, our Bella seems to be struggling with early myco and a possible secondary. The immune systems of these little creatures are just so fragile.  Huh

Oh, and Lenore....good luck with your little snowball looking sweetie.

Thanks,

Rog
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« Reply #14 on: May 03, 2003, 10:45:43 AM »

Can anyone point me to a documented clinical study on enrofloxacin's effects on young rodents? Or perhaps a personal experience with the joint damage caused by the medication ?

as scout mentioned there is none - i honestly do not believe that there has been any actual problem with the drug in young rats at all - because the people thought it was "stunting growth" because someone thought they read that (which is not what the studies say, as we posted). and i am not sure if it was causing any damage to the formation of the cartilage in the joint that we would see the effects - because it was most damaging to large breed dogs during their growth spurt - and rats do not have a big growth spurt Smiley

that being said, i have used baytril when i needed to on younger animals that required it, to no ill effect. all the rats i used it on are normal sized if not extra large, and happy and relatively healthy. almost all my personal rats were on it as youngsters due to an unexplained death (taht ended up being congenital) -- i put all my rats on it immediately just in case, and none suffered at all Smiley

so wish i could be of more help, but i have used baytril and will use it in the future if called for on youngsters if i need to.

however, i DO opt for SMZ over all other meds for youngsters (or ANY rat) beacuse i have had the best luck with it over any medication, it tastes good, is very inexpensive, and works for me!! i love it!
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« Reply #15 on: May 03, 2003, 12:26:55 PM »

Kim, I'm curious because I respect your opinion very much: the vet deliberately chose Doxy because it is active against myco, since she doesn't know if the secondary infection is bacterial or viral. Do you think this is a reasonable course of action? I mean, I'm guessing SMZ wouldn't be as helpful with a viral infection since it doesn't target myco?

Update on Elmo: He's doing about the same. He's not too thin, but not nearly as fat as his sisters and brothers, so I'm trying to give him quiet time with the mommies so he doesn't have to fight for food. If I don't see him eat by this afternoon I'm going to give him baby formula so that I know he's getting something. He's also getting steam treatments and has had a couple teeny infinitesimal doses of Sudafed. I've never dealt with a sick rat this young, so any advice on how to make him comfortable is appreciated.
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« Reply #16 on: May 03, 2003, 02:00:56 PM »

i have personally not used doxy (i actually used the premade vibramycin) in awhile, and did not have amazing luck with it on my young ones (the adults seemed to respond a bit but nowhere near as much as when combined with baytril).

myco is actually not a virus, but a bacterium (though modified and does not act like a normal bacteria). and remember, no antibiotic is really active against viruses -- they can only treat secondary infections. so no matter what you choose, if the rat has a viral infection, you arent treating that actual VIRUS 99% of the time - you are providing supportive care and working with secondary opportunistic infections (think SDA).

i use SMZ because it seems to kick out any secondary infections much quicker than other meds i have used, and it has the added bonus of being widely active and very penetrating (i love it for skin problems too!). it tastes good, i do not have to give a lot, and its just been a heck of a lot more effective than other meds. i do not like to use baytril (since i think it is largely abused now by the rat community/vets as the "end all") and when i use doxy i usually use it with baytril to get it to be most effective -- hence, i stick with SMZ Smiley

and i am sure you are doing it already, but soy milk, soy milk, soy milk Smiley
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« Reply #17 on: May 03, 2003, 06:38:02 PM »

myco is actually not a virus, but a bacterium (though modified and does not act like a normal bacteria). and remember, no antibiotic is really active against viruses -- they can only treat secondary infections. so no matter what you choose, if the rat has a viral infection, you arent treating that actual VIRUS 99% of the time - you are providing supportive care and working with secondary opportunistic infections (think SDA).

Actually, that was my point. Since the vet thinks the secondary infections could be viruses (and thus unresposive to antibiotics), her plan was to attack the myco and hopefully the immune system will boot out whatever the secondary infection is. Since the drug chart says SMZ doesn't attack myco directly, it wouldn't be the best drug to use for this purpose, am I correct? I was just curious about your opinion of her treatment plan. Thanks for your input anyway; I suppose we'll jut have to wait and see how he does.
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« Reply #18 on: May 04, 2003, 01:41:10 PM »

Ok, stupid question. What are SMZ and TMS? Huh

Thanks.

Suzanne
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« Reply #19 on: May 04, 2003, 01:44:08 PM »

hey lenore - sorry i didnt see your reply last night Smiley
i understand now what the vet was saying -- just a quick question -what makes her think the secondary infections are viral and not bacterial? i have no idea how to differentiate....


and TMS/SMZ is also known as bactrim and a BUNCH of other names -- its Trimethoprim/sulfamethoxazole
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« Reply #20 on: May 04, 2003, 02:07:07 PM »

what makes her think the secondary infections are viral and not bacterial? i have no idea how to differentiate....

LOL, the vet doesn't know how to differentiate either. I suppose she could do a culture or something, but it seems like overkill for a pretty run-of-the-mill URI. That's why she prefered to attack the myco, because if the secondary infection is viral then treating it wouldn't be very effective.
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« Reply #21 on: May 06, 2003, 07:17:49 PM »

Well, four days later and, surprise surprise, the Doxy isn't working. He's just as loud, but still eating and drinking like nobody's business. So I had him weighed again today (he's gained 50% to a whopping 63 grams!), and the vet is going to call later about putting him on something else (she wasn't available when I went in).

A major concern she had the first time was the lack of data on giving Zithro to such a young rat, so if any of you vet-types or breeders or other awesome rat people have any data about that, could you send it this way? Mwah.   Heart
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« Reply #22 on: May 07, 2003, 05:01:26 AM »

we used baytril with my snuffy when he developed pneumonia at about 6-7 weeks. he's 20 months old now and has suffered no noticible effects. he was very sick though and i am glad that my vet didn't mess around trying less potent drugs.

6-7 weeks is also a good bit different than 3 weeks.

i hope you can find something that works for your tiny guy. he's adorable!
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« Reply #23 on: May 08, 2003, 10:35:37 PM »

Okay, so this afternoon we moved Elmo back in with Lady Grey so he can keep nursing (Tess is in a separate cage now that we know she's expecting). And a few hours later when I took him out, he wasn't heaving or rattling! He's still a bit sneezy, but the weird breathing noises are totally gone. As fast as he got sick, he got better.

Maybe he just needed his mommy; whatever the cause, I feel a lot less stressed out now. He has another appointment to be weighed and checked tomorrow since I'm keeping him on meds for at least another week, depending on if this remission lasts. Thank you for all your help, everyone.   Heart
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