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prednisone vs prednisolone
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Topic: prednisone vs prednisolone (Read 107 times)
aydenann
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prednisone vs prednisolone
«
on:
October 07, 2008, 08:26:24 PM »
Has anyone here had any experience using prednisolone in place of prednisone in rats? If so, is the dosage the same?
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Claymore
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Re: prednisone vs prednisolone
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Reply #1 on:
October 07, 2008, 10:18:54 PM »
This should help out.
http://ratguide.com/meds/endocrine_hormones/prednisone_prednisolone.php
Prednisone is converted to prednisolone in the liver, so all it is is the synthetic version of what the liver converts the prednisone into.
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Re: prednisone vs prednisolone
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Reply #2 on:
October 08, 2008, 07:24:45 AM »
from ratguide
Though prednisone and prednisolone are used in the same manner and equally as effective, they should not be confused with each other. Prednisone is activated by the liver into prednisolone. For this reason, and because it is more easily absorbed, prednisolone is the drug of choice when hepatic disease or insufficiency is present.
I actually use dexamethasone myself, because its faster acting and lasts for a longer duration, but most people use pred.
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The Rat Shack
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Re: prednisone vs prednisolone
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Reply #3 on:
October 08, 2008, 11:42:35 AM »
Also, remember that you have to taper off of giving Pred to any pets. It can't be stopped cold turkey. You'll usually see increased activity, increased thirst/eating and increased urination when Pred is given too.
Deb
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Deb F. (Certified Vet Tech)
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Lise
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Re: prednisone vs prednisolone
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Reply #4 on:
October 08, 2008, 01:04:04 PM »
I would check with your vet about dosages to be sure. Rat guide only lists one dosage range, but I thought I recalled that they were different for predisone vs prednisolone.
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Re: prednisone vs prednisolone
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Reply #5 on:
October 08, 2008, 01:12:29 PM »
I agree with Lise. The dosage is a range and would be given depending on the amount of immune response suppression that you need. In my exotics formulary, the only drug listed is prednisone and the dosage range is 0.5 to 2.2 mg/kg to be given by mouth, subcutaneous or intramuscular. It is indicated to be safe for all species of rodents as an anti-inflammatory.
Deb
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Deb F. (Certified Vet Tech)
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aydenann
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Re: prednisone vs prednisolone
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Reply #6 on:
October 08, 2008, 03:34:16 PM »
Thank you to everyone for all the info.. I should have thought to check The Rat Guide myself. Don't know where my head was
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