Every couple days I take a pail of hot water and wipe down the wires. I do this with my boys in their cage, they seem to think its a fun game to chase around the hot rag
This way, it lasts longer before I have to do a full cleaning, a ruud is a PITA to clean in my bathtub.
If they are going to be out of the cage and you plan on doing a complete cleaning, you could use hot water with bleach but you need to make sure you rinse it off very well. When I clean I rinse it off, take soap and give it a good scrub, rinse it off, spray simple green everywhere, let it sit a couple minutes, and rinse it off very well. Hope this helped.